6 Sections
16 Lessons
8 Weeks
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Section 1 — Biology & Bioinformatics Foundations
4
1.1
Major Topics: PDB • UniProt • Multiple Sequence Alignment (MSA) • BLAST • HHblits • Phylogenetics
1.2
Module 2 — Structural Bioinformatics | Week 2 Explore essential structural bioinformatics resources and sequence-analysis concepts used in computational protein research.
1.3
Major Topics: DNA • RNA • Proteins • Amino Acids • Protein Folding
1.4
Module 1 — Molecular Biology Fundamentals | Week 1 Develop the biological foundation required for protein structure prediction.
Section 2 — AI & Deep Learning Foundations
2
2.1
Module 3 — Deep Learning Foundations | Week 3 Understand important AI concepts behind modern protein-prediction systems.
2.2
Major Topics: Transformers • Attention • Graph Neural Networks (GNNs) • Protein Embeddings
Section 3 — AlphaFold Fundamentals
4
3.1
Module 4 — AlphaFold Fundamentals | Week 4 Explore the development of protein structure prediction and the evolution of AlphaFold.
3.2
Major Topics: AlphaFold History • CASP • AlphaFold 1–3 • Traditional Protein Structure Prediction Methods
3.3
Major Topics: Evoformer • IPA • Recycling • Confidence Metrics
3.4
Module 5 — AlphaFold 2 Architecture | Week 5 Study the major architectural concepts underlying AlphaFold 2.
Section 4 — Practical AlphaFold
2
4.1
Module 6 — Practical AlphaFold | Week 6 Move from theoretical concepts to practical AlphaFold workflows.
4.2
Major Topics: Installation • Inference • Protein Structure Visualization • Optimization
Section 5 — Advanced Protein AI
2
5.1
Module 7 — Advanced Protein AI | Week 7 Explore advanced AI approaches and tools used within computational protein science.
5.2
Major Topics: AlphaFold-Multimer • Protein Language Models • OpenFold • Drug Discovery
Section 6 — Research & Capstone
2
6.1
Module 8 — Research & Capstone | Week 8 Apply course concepts to research-oriented problems and explore responsible applications of AI in biomedical science.
6.2
Major Topics: Biomedical Applications • Benchmarking • Ethics • Final Project
AlphaFold and AI for Protein Structure Prediction
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